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doi: 10.1074/jbc.274.18.12675 13

Aldose reductase (AR) is the first and rate-limiting enzyme of polyol pathway responsible for the reduction of glucose to sorbitol, which is further metabolized to fructose by sorbitol dehydrogenase under hyperglycemic status

Conclusions Nutraceuticals represent promising strategies for preventing, delaying, and addressing premature aging of the skin, especially as women advance in years (particularly after 30 years of age, when estrogen levels begin to decline and remarkably after menopause when estrogen production ceases from the ovaries)

Reduces hyperpigmentation, melasma, sun damage, and acne scars

FIGURE 2 3 The activation mechanism of eryptosis in renal anemia In the uremic milieu of CKD, a constellation of factorsincluding uremic toxin accumulation, chronic inflammation, oxidative stress, and hypoxiaconverge to induce cellular damage signals that promote eryptosis, the programmed death of erythrocytes